Atopic dermatitis is a chronic inflammatory skin disease affecting 10-20% of children and 1-3% of adults worldwide. Pruritus (itch) prevalence in atopic dermatitis patients is greater than 80% and greatly impairs their quality of life by causing sleep and psychological disturbance.

Notalgia Parasthetica is a chronic neurological condition characterized by localized pruritus/itch at the base of the shoulder blade, that may constitute as much as 8% of patients with chronic pruritus/itch. It is more common in adults between 40 and 80 and 2-3 times more common in women than men. There are no currently approved drugs for the treatment of this condition and the symptoms of itching and burning may affect the patients quality of life.

Chronic hand eczema (CHE) is an underserved condition with high unmet need, impacting up to 10% of adults, with no approved treatments in the US and few available off-label options. CHE has a significant negative impact on quality of life, including psychosocial health and workforce productivity, and can lead to a number of comorbidities such as sleep disturbance and depression.

Osteoarthritis (OA) is a degenerative joint disease with no approved disease modifying therapies. OA is a major cause of disability and impaired quality of life affecting more than 230 million patients globally.